Type:

Other

Description:

A common polymorphism (R577X) in the ACTN3 gene results in complete deficiency of -actinin-3 protein in 16% of humans worldwide. The presence of -actinin-3 protein is associated with improved sprint/power performance in athletes and the general population. Despite this, there is evidence that the null genotype XX has been acted on by recent positive selection, likely due to its emerging role in the regulation of muscle metabolism. -Actinin-3 deficiency reduces the activity of glycogen phosphorylase and results in a fundamental shift toward more oxidative pathways of energy utilization.

Subjects:

  • Education > General

Education Levels:

    Keywords:

    Actin filament,NSDL,Glycogen,NSDL_SetSpec_BEN,oai:nsdl.org:2200/20110722024512782T,Life Science,Education,Oxidative,Teacher-centered/traditional instruction,Tutorial or self-directed instruction,Gene expression,Physiology,Student-centered instruction

    Language:

    English

    Access Privileges:

    Public - Available to anyone

    License Deed:

    Creative Commons Attribution Non-Commercial Share Alike

    Collections:

    None
    This resource has not yet been aligned.
    Curriki Rating
    'NR' - This resource has not been rated
    NR
    'NR' - This resource has not been rated

    This resource has not yet been reviewed.

    Not Rated Yet.

    Non-profit Tax ID # 203478467