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Description:

Ubiquitin ligases determine protein stability in a highly regulated manner by coordinating the addition of polyubiquitin chains to proteins that are then targeted to the proteasome for degradation. Ubiquitin ligases have generally been separated into two groups--those containing HECT domains and those with RING finger domains. Recently, a third group of ubiquitin ligases has emerged: those containing a U-box domain. Patterson discusses what is known about the few U-box-containing proteins that have been characterized, although the general properties of U-box proteins that distinguish them from other ubiquitin ligases are still a matter of speculation.

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      Keywords:

      NSDL,proteasome,CHIP,signal transduction,Ecology, Forestry and Agriculture,degradation,oai:nsdl.org:2200/20080618222543037T,NSDL_SetSpec_BEN,Life Science,RING,Geoscience,ubiquitination

      Language:

      English

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      Public - Available to anyone

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      Creative Commons Attribution Non-Commercial Share Alike

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