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Access to the article is free, however registration and sign-in are required. Model organisms such as yeast have proved exceptionally valuable for revealing new information about the molecular pathways involved in the aging of cells. In her Perspective, Campisi comments on new work showing that caloric restriction increases longevity in yeast by activating the SIR2 gene, which alters the compactness of chromatin and thus regulates gene expression (Lin et al.).

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      Keywords:

      DNA damage,SIR2 gene,NSDL,NSDL_SetSpec_BEN,life-span,caloric restriction,oai:nsdl.org:2200/20110722023131161T,Life Science,gene expression

      Language:

      English

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      Public - Available to anyone

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      Creative Commons Attribution Non-Commercial Share Alike

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