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In glioblastomas, an Akt-independent, PTEN (phosphatase and tensin homolog deleted on chromosome ten)–regulated signaling pathway links EGFR (epidermal growth factor receptor) to the phosphorylation of TOR (target of rapamycin) and of the ribosomal protein S6 and to the control of cell replication. Although PKCα (protein kinase Cα) has been identified as an essential component, the detailed wiring of this previously unexplored noncanonical pathway remains to be worked out.
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