The dynamic profiles show the variation of different process variables in a typical fed-batch culture of hybridomas to produce monoclonal antibodies. The user can vary a number of process variables that a fed-batch operator can implement in a real fed-batch process, such as the initial volume, initial glutamine concentration, feeding rate, threshold concentration of glutamine at which feed is turned on, inoculum (initial viable cell concentration), and the duration of fed-batch culture. The objective of these interactive dynamic simulations is to maximize the amount (grams) of antibody accumulated at the end of fed-batch culture by varying all the process variables indicated in the sliders above. Another objective can be to maximize the average volumetric production rate (gram/liter/day). The volume of the bioreactor is fixed at 100 liters.


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