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Access to the article is free, however registration and sign-in are required. The structure of the core of an enzyme complex that senses and responds to changes in the cell's energy balance has been solved. Adenosine monophosphate-activated protein kinase (AMPK) complex regulates cellular energy balance. On page 1726 of this issue, Townley and Shapiro (2) describe crystal structures for the core of the AMPK complex from fission yeast. The study provides insights into binding of AMP and adenosine triphosphate (ATP), which may be very helpful in the design of new drugs that might treat disorders of energy balance (i.e. obesity and type-2 diabetes).
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