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Access to the article is free, however registration and sign-in are required. Diffusion of the membrane-fusion protein syntaxin in cell membranes can be explained by a simple model of attraction and repulsion. Sieber, Lang, and co-workers refreshingly turn our attention back to the problem of simple diffusion and clustering of proteins in fluid membranes. They show that the clustering of syntaxin 1 in the plasma membrane of neuroendocrine PC12 cells can be described by a simple physical model. The work is particularly notable because of the importance of syntaxin 1 in the docking and fusion of secretory vesicles to allow external release of their contents (exocytosis).
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