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Access to the article is free, however registration and sign-in are required. New studies increase the number of protein-protein interactions but show little overlap. This is not a bad thing, though. On page 104 in this issue, Yu et al. (4) identify 1809 2-dimensional protein interactions in the model organism budding yeast, of which more than 1500 are new relative to the early yeast two-hybrid studies (2, 3). Together with the 2770 interactions recently determined by Tarassov et al. by a protein complementation assay (5), almost all of which are new, the number of binary interactions has more than tripled relative to earlier analyses (2, 3). These studies bring us closer to a complete map of biophysical interactions in a single organism, and hence to the ultimate goal of functional understanding of the cellular machinery in space and time (6).
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