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Access to the article is free, however registration and sign-in are required. The unique stalk of the molecular motor protein dynein may serve as a smart tether rather than as a lever during motion along microtubules. Dynein is a molecular motor protein responsible for the movement of organelles, vesicles, and macromolecular complexes, for several steps in mitosis, and for flagellar and ciliary beating. It moves toward the minus ends of microtubules, the filamentous track used for long-distance transport in eukaryotic cytoplasm. On page 1691 of this issue, Vale and co-workers (1) report a crystal structure showing the stalk that protrudes from dynein's motor domain and interacts with a microtubule.
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