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Access to the article is free, however registration and sign-in are required. In the area of systems biology, networks of interacting proteins have been explored as models for understanding cellular processes. Many of these networks exhibit a "small world" property, meaning that a connection can be established between any two elements of the network by following only a small number of links. This is due in part to the presence of hubs, which are elements connected to many other elements in the network. Kim et al. add a new chapter to the analysis of hubs in protein interaction networks, clarifying some previously murky issues about how they operate in the cell and how they may have evolved.
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