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Technologies developed at Oak Ridge National Laboratory include: 1) use of nanoprobes based on plasmon-resonance (which is defined) to enhance surface Raman scattering and fluorescence; 2) an optical neurosensor based on a 40 nm fiber optical tip; and 3) a multifunctional biochip capable of DNA and other protein-based bioassays. The article is available for download in PDF format with several illustrative graphics. Although insufficient in details to duplicate experimentally, the article does provide a nice overview of how development of small-scale analytical measurements can be used to address important biological problems. This 6 page article was presented at the First International Symposium on Micro and Nano Technology in 2004. A list of references appears at the end.
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