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Other

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Access to the article is free, however registration and sign-in are required. Proteins on the cell surface can be cleaved by proteolytic enzymes. In the Perspective, Werb and Yan outline the many purposes of these cleavage events-to provide ligand for binding to receptors (as shown in the report by Peschon et al. on p. 1281), to eliminate ligand on receptors and to increase or decrease cell-cell interactions. Such proteolysis can be regulated and is turning out to be widely used by the cell.

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      Keywords:

      membrane proteins,sheddases,tumor necrosis factor-a (TNF-a) converting enzyme (TACE),NSDL,NSDL_SetSpec_BEN,ectodomains,proteolysis,oai:nsdl.org:2200/20110722023158721T,proteinase

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      English

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      Creative Commons Attribution Non-Commercial Share Alike

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