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Access to the article is free, however registration and sign-in are required. Cell movement is an elegant orchestration of different cellular processes that include microtubule dynamics, contraction of actin and myosin filaments, and the formation and turnover of integrin-rich adhesion complexes that serve as traction points over which the cell moves. In a comprehensive overview Perspective, Horwitz and Parsons discuss the mechanisms that regulate the dynamics of contractile forces and adhesion. New findings suggest the existence of a molecular `clutch' that regulates the balance of these processes (Smilenov et al.).
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