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Access to the article is free, however registration and sign-in are required. Yersinia, the genus of bacteria that produced the Black Plague, has devised a specialized secretion mechanism that injects toxic protein into cells. Silhavy describes this type III secretion mechanism, including the new results presented on p. 1140 of this issue that identify the targeting signal for these proteins. Unlike the signal sequences of many conventionally secreted proteins, which are located within the protein, the targeting information for these secreted proteins actually lies within their messenger RNA.
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