Type:

Other

Description:

Access to the article is free, however registration and sign-in are required. It is known that processes such as cell migration involve adhesion of cells to the extracellular matrix via integrins. However, the integrin-mediated signaling events that help to regulate various cellular functions are still being elucidated. In his Perspective, Guan discusses new work (del Pozo et al.; Palazzo et al.) demonstrating that integrins use plasma membrane lipid rafts to regulate the targeting of Rac and Rho GTPases to the plasma membrane and their coupling to downstream effector molecules.

Subjects:

  • Mathematics > General

Education Levels:

    Keywords:

    NSDL,NSDL_SetSpec_BEN,oai:nsdl.org:2200/20110722030427393T,lipid rafts,Rac GTPases,signaling pathways,Life Science,Mathematics,regulation

    Language:

    English

    Access Privileges:

    Public - Available to anyone

    License Deed:

    Creative Commons Attribution Non-Commercial Share Alike

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