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Access to the article is free, however registration and sign-in are required. When their genetic material is damaged, cells prudently refrain from starting cell division (or mitosis). A prominent component of the cellular machinery that puts this brake on the cell, the protein Rad9, has now been identified by Sun et al. Walworth explains in her Perspective how this work now suggests a mechanism by which Rad9 and another protein Rad53 stop the cell cycle.

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      Keywords:

      DNA damage,NSDL,protein kinase,NSDL_SetSpec_BEN,oai:nsdl.org:2200/20110722030211597T,mitosis,Rad53,cell cycle checkpoint pathway,Life Science

      Language:

      English

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