Type:

Other

Description:

Background/Aims: Heart rate variability (HRV) is reduced in several clinical settings associated with either systemic inflammation or neuropsychiatric impairment. The possibility that the changes in HRV observed in patients with neuropsychiatric impairment might relate to the overproduction of inflammatory cytokines does not seem to have been considered in the studies undertaken to date. HRV is decreased in patients with liver cirrhosis but its relationship to the impairment of neuropsychiatric performance, commonly observed in these patients, is unknown. The aim of this study was to investigate the relationship between HRV, hepatic encephalopathy and production of inflammatory cytokines in patients with cirrhosis. Methods: Eighty patients with cirrhosis (53 men, 27 women; mean [±1SD] age 54±10 yr), classified as neuropsychiatrically unimpaired or as having minimal/overt hepatic encephalopathy, and 11 healthy subjects were studied. HRV was assessed by applying Poincaré plot analysis to the R-R interval series on a five minute ECG. Inflammatory cytokines (TNF-alpha, IL-6, IL-10, and IL-12) were measured in a subgroup of patients. Results: Long-term R-R variability was significantly decreased in the patients with cirrhosis, in parallel with the degree of neuropsychiatric impairment (p

Subjects:

  • Education > General

Education Levels:

    Keywords:

    Education,Cytokine,NSDL,NSDL_SetSpec_BEN,Life Science,oai:nsdl.org:2200/20090420201229167T,Liver,Heart rate,Teacher-centered/traditional instruction,Tutorial or self-directed instruction,Student-centered instruction

    Language:

    English

    Access Privileges:

    Public - Available to anyone

    License Deed:

    Creative Commons Attribution Non-Commercial Share Alike

    Collections:

    None
    This resource has not yet been aligned.
    Curriki Rating
    'NR' - This resource has not been rated
    NR
    'NR' - This resource has not been rated

    This resource has not yet been reviewed.

    Not Rated Yet.

    Non-profit Tax ID # 203478467