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Biological systems (e.g. cells) can make stochastic transitions between phenotypes (e.g. states of relatively increased or decreased drug resistance). This means that an initially drug-sensitive population can generate relatively drug-resistant subpopulations. This video presents a metronomogram, which is a tool for understanding whether such stochastic transitions can provide an opportunity for therapeutic treatment. Citation: Liao D, Estevez-Salmeron L, and Tlsty TD (2012) "Conceptualizing a tool to optimize therapy based on dynamic heterogeneity," Phys. Biol. 9:065005.
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