Gramene is a "curated, open-source, Web-accessible data resource for comparative genome analysis in the grasses," funded by the United States Department of Agriculture. The searchable database, containing data derived from related public projects, may be queried with the rice genome browser, blast search, map search, or phenotype search, to name just a few. Gramene is frequently updated; recent changes include new tracks and updated sequence alignments in the genome browser. A number of downloads are available, including genetic maps, microsatellites, sequence databases, software, and more. This site is intended for researchers investigating cross-species homology relationships in grass species.