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This synopsis covers 8 questions and the associated background, observations, and significance. The questions are: 1. How does eating "junk food" during pregnancy and/or lactation affect the metabolism of offspring? 2. Do the abnormalities in Ca2+ signaling observed in AlzheimerÂs disease (AD) contribute to the pathogenesis of the disease? 3. What can the crystal structure of a sodium galactose transporter reveal about the molecular mechanism of Na+/glucose cotransporter proteins (SGLTs)? 4. Does AMP-activated protein kinase (AMPK) have a role in smooth muscle contraction? 5. Does a mutation in the cardiac calsequestrin gene (CASQ2) result in the rare autosomal recessive form of catecholaminergic polymorphic ventricular tachycardia (CPVT)? 6. How are substrates translocated by neurotransmitter:sodium symporters? 7. How is ATP release form biliary epithelial cells induced? 8. How does the Ca2+-activated fusion process occur in various cell types?
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