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Other

Description:

Onset of Type 2 diabetes occurs when the pancreatic Beta-cell fails to adapt to the increased insulin demand caused by insulin resistance. Morphological and therapeutic intervention studies have uncovered an inflammatory process in islets of patients with Type 2 diabetes characterized by the presence of cytokines, immune cells, ?-cell apoptosis, amyloid deposits, and fibrosis. This insulitis is due to a pathological activation of the innate immune system by metabolic stress and governed by IL-1 signaling. We propose that this insulitis contributes to the decrease in Beta-cell mass and the impaired insulin secretion observed in patients with Type 2 diabetes.

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      Keywords:

      Content/background information,NSDL,NSDL_SetSpec_BEN,oai:nsdl.org:2200/20110722024225613T,Inflammation,Life Science,Diabetes,Pancreas

      Language:

      English

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      Public - Available to anyone

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      Creative Commons Attribution Non-Commercial Share Alike

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