This resource was reviewed using the Curriki Review rubric and received an overall Curriki Review System rating of 2, as of -0001-11-30.
This resource received a 2* rating because it is part of Molecular Genetics, which received a rating of 2-Good in the Curriki Review System and which you can see here:…
This lesson plan was created based on a template developed for the Curriculum, Instruction & Assessment initiative sponsored by the Alliance for Catholic Education.
Number of Days:
SWBAT transcribe a DNA sequence and translate an RNA sequence.
SWBAT apply the process of translation to analyze mutations in a gene.
Benchmark or Standards:
B.1.23 Understand that and describe how inserting, deleting, or substituting DNA segments can alter a gene. Recognize that an altered gene may be passed on to every cell that develops from it, and that the resulting features may help, harm, or have little or no effect on the offspring’s success in its environment. B.1.26 Demonstrate how the genetic information in DNA molecules provides instructions for assembling protein molecules and that this is virtually the same mechanism for all life forms.
Projector, laptop, X-men video
open-ended questioning (X-men), predicting before concluding
Method or Procedure
Students are given a strand of DNA, and they must transcribe and translate this strand. Then, they must change one base on that strand, and transcribe and translate this new sequence. What do you notice?
Explain the different types of DNA mutations
Predict the consequences of different DNA mutations on the amino acid sequence. If you substitute a DNA base pair, will the amino acid always have the same change?
Explain how the mutations in DNA result in different amino acid mutations. Use a graphic organizer showing the original DNA strand, the DNA mutation, the RNA strand, and the Amino Acid strand
Graphic organizer, questioning
Is a DNA mutation ALWAYS bad?
BW: Do you think it is possible to create X-Men from mutations? (Show video clip of X-men that describes how they were the result of "mutations")
Discuss BW: begin to focus on the idea of how mutations may or may not effect an organism, and the extent to which they may cause change in the phenotype of the organism.
Transcription, translation, and mutations worksheet. Students will be given DNA sequences to transcribe and translate. Then, they will make DNA mutations and analyze the effect of these mutations on the amino acid strands.
HW: Study for quiz on transcription, translation, and mutations
BW: Review for quiz, finish going over the pair-work from yesterday
Independent & Individual
Answer questions from the quiz
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