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In the Hollywood movie GATACCA, an infant's genome sequence is produced in seconds and the probabilities of dozens of chronic disorders roll off the screen. Although real-world progress in technologies for DNA sequencing seems to be approaching the science fiction version of genomics, the ability to predict an individual's risk of chronic disease based on DNA sequence is lagging behind. How do we bridge this gap? Or is it time to reconsider the goal of accurately predicting individual risk?
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