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Access to the article is free, however registration and sign-in are required. a-dystroglycan and its sibling, b-dystroglycan, sit on the cell surface, bridging the membrane. Inside the cell, they connect with the cytoskeleton, and outside the cell they connect with components of the extracellular matrix. In her Perspective, Spear discusses new evidence in this issue (Rambukkana et al. and Cao et al.) that these proteins are also the receptors for the agents of two very different diseases--leprosy and Lassa fever.
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