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Access to the article is free, however registration and sign-in are required. In Carl Nathan's Perspective, he discusses a type of relationship between antimicrobial chemotherapy and host immunity: An antibacterial agent can mimic immunity by generating an important chemistry of the immune response (4) .Singh et al. find that nitroimidazoles kill Mycobacterium tuberculosis (Mtb) under hypoxic conditions at least in part by undergoing enzyme-catalyzed denitration, which generates reactive nitrogen intermediates.
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