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Access to the article is free, however registration and sign-in are required. Part of the reason that Mycobacterium tuberculosis is such a successful pathogen is that it has learned how to survive inside the lysosomes of host macrophages. In their Perspective, Pieters and Ploegh describe one reason for the success of this microbe: Its proteasomes are able to protect mycobacterial proteins against attack by nitric oxide and its derivatives, which are produced inside the macrophage lysosomes (Darwin et al.).
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