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Access to the article is free, however registration and sign-in are required: There is an urgent need to develop new therapeutics against the microbe causing anthrax, which has the potential to be used in biological warfare. In their Perspective, Olsnes and Wesche discuss a new therapeutic approach designed by Sellman and colleagues. In this approach, a mutant subunit of the toxin prevents correct assembly of wild-type subunits into a pore in the host cell membrane. In this way, lethal bacterial enzymes are prevented from translocating into the host cell.

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      Keywords:

      lethal factor (LF),protective antigen (PA),NSDL,NSDL_SetSpec_BEN,biological weapon,biological warfare,mutant (dominant-negative) PA subunit,lethal bacterial enzymes,translocating,oai:nsdl.org:2200/20110722031021113T,Bacillus anthracis,edema factor (EF)

      Language:

      English

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      Public - Available to anyone

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      Creative Commons Attribution Non-Commercial Share Alike

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