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Access to the article is free, however registration and sign-in are required: Microbiologists have long been puzzled by the finding that the gut mucosa does not respond to the myriad varieties of bacteria that normally reside in the gut. As Xavier and Podolsky explain in their Perspective, this may be because bacteria that are indigenous to the gut have learned ways to switch off pathways in gut epithelial cells that lead to switching on of genes involved in inflammation (Neish et al.).

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      Keywords:

      gut microflora,innate immune response,inhibition of NF-kB activation,NSDL,NSDL_SetSpec_BEN,oai:nsdl.org:2200/20110722031030933T,gut mucosa,commensal microbe,inflammatory cytokines,pathogenic microbe,host inflammatory response,immune tolerance

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      English

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