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Access to the article is free, however registration and sign-in are required. Sturm et al. report a major twist to this story during the liver stage of malaria infection. Using Plasmodium berghei, a mouse model of malaria, they show that the liver-stage parasite keeps its host hepatocyte alive long enough to complete development but allows it to then commit an unusual form of suicide that helps the parasite evade host defenses and deposit new invasive forms into the bloodstream. Membranous vesicles shuttle malaria parasites from liver to blood cells during infection, ensuring protection against the host's defenses.

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      Keywords:

      stages of malarial disease,Plasmodium,NSDL_SetSpec_BEN,mosquito bite,merozoites,Life cycle of Plasmodium,erythrocytes,oai:nsdl.org:2200/20110722025952535T,sporozoite,evasion of the immune system,hepatocytes,malaria parasite,merosomes,NSDL

      Language:

      English

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      Creative Commons Attribution Non-Commercial Share Alike

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