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Access to the article is free, however registration and sign-in are required. Forty years ago, as the first drug- and insecticide-based global malaria eradication plan was being abandoned, the concept was raised of using evolutionary genetics to fight vector-borne diseases like malaria, dengue, and river blindness (1).The idea was to exploit selfish genetic elements, entities that can spread through host populations by distorting normal Mendelian inheritance, thereby enhancing their own transmission. In a Perspective by Read and Thomas, they discuss how McMeniman et al. (2) report a major step in a lateral development of this approach. They have infected the mosquito species that transmit dengue viruses to humans with an inheritance-distorting bacterium that kills mosquitoes likely to be infectious.
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