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Access to the article is free, however registration and sign-in are required: For 30 years biologists have studied the molecular machinery of staphylococcal bacteria that renders them resistant to b-lactam antibiotics. In a Perspective, Archer and Bosilevac discuss new findings showing that cleavage of a sensor-transducer protein after it binds to a b-lactam antibiotic results in cleavage of the repressor protein that binds to the blaZ gene. b-Lactamase is then produced and binds to and inactivates the antibiotic.

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      Keywords:

      antibiotics resistance,blaZ,transpeptidase enzymes (penicillin-binding proteins),NSDL,NSDL_SetSpec_BEN,sensor-transducer,mecA,proteolytic cleavage,oai:nsdl.org:2200/20110722031024485T,repressor,b-lactam antibiotics,mobile elements,Gram-positive bacteria

      Language:

      English

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      Public - Available to anyone

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      Creative Commons Attribution Non-Commercial Share Alike

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