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Access to the article is free, however registration and sign-in are required. Detailed knowledge of the dynamics of biomolecules is crucial for the treatment of human diseases, but is often hard to come by. In his Perspective, Pratt highlights the report of Dian et al., who have developed a method for manipulating the populations of different conformational states of small biomolecules that allows distinct folding pathways to be distinguished. If the method can be extended to larger molecules, it should provide important insights into their dynamics.
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