Although Mendel's laws were first tested in pea plants and fruit flies, evidence quickly mounted that they applied to all living things. Just as mutations had provided keys to understanding fruit fly genetics, pedigrees of families affected by diseases provided many of the first examples of Mendelian inheritance in humans. Recessive inheritance was first described for the disorders alkaptonuria (1902) and albinism (1903). Among the first dominant disorders discovered were brachydactyly (short fingers, 1905), congenital cataracts (1906), and Huntington's chorea (1913). Duchenne muscular dystrophy (1913), red-green color blindness (1914), and hemophilia (1916) were the first sex-linked disorders. The simple concept of eye color inheritance — brown is dominant, blue is recessive — was published in 1907; however, scientists now believe that several genes are involved.


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