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Other

Description:

The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid–induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.

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      Keywords:

      NSDL,cancer,NSDL_SetSpec_BEN,signal transduction,oai:nsdl.org:2200/20100927005257400T,substrate specificity,Life Science

      Language:

      English

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      Public - Available to anyone

      License Deed:

      Creative Commons Attribution Non-Commercial Share Alike

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