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Access to the article is free, however registration and sign-in are required: lin-4, an evolutionarily conserved microRNA, and its regulatory target lin-14, encoding a nuclear protein, constitute a biological timing mechanism that advances Caenorhabditis elegans larval development. In his Perspective, Antebi discusses the report by Boehm and Slack that shows how these components may also regulate adult longevity. The microRNA and its target may work through DAF-16/FOXO, a forkhead transcription factor that extends life in diverse species. Hence, biological timers may regulate aging.

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      Keywords:

      aging,forkhead transcription factor,lin-4 microRNA,NSDL_SetSpec_BEN,oai:nsdl.org:2200/20110722025518184T,lin-14,insulin/IGF-1 signaling,NSDL

      Language:

      English

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      Creative Commons Attribution Non-Commercial Share Alike

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