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Access to the article is free, however registration and sign-in are required. ATP is the energy currency of the cell: hydrolysis of ATP into ADP and inorganic phosphate (Pi) releases energy. The enzyme responsible for generating this energy currency is the ATP synthase. In a Perspective, Fillingame discusses two new reports (Sambongi et al. and Stock et al.) that present an elegant structural model of how ATP synthase works: it behaves like a tiny molecular rotary motor, coupling the mechanical force of an electrochemical proton gradient to the formation of the chemical bond between ADP and Pi.
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