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Other

Description:

The ubiquitous Galphas-subunit of the trimeric, stimulatory G-protein plays a central role in receptor-mediated signal transduction, coupling receptor activation with the production of cAMP. The Galphas-encoding locus Gnas is now known to consist of a complex arrangement of several protein-coding and noncoding transcripts. We provide an overview of its genomic organization, its regulation by genomic imprinting, and a summary of the physiological roles of the alternative protein variants Galphas and XLalphas as determined from deficient mouse models.

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      Keywords:

      Content/background information,NSDL,G protein,Signal transduction,Transgenic model,NSDL_SetSpec_BEN,Life Science,oai:nsdl.org:2200/20110722031514375T

      Language:

      English

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      Public - Available to anyone

      License Deed:

      Creative Commons Attribution Non-Commercial Share Alike

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