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Access to the article is free, however registration and sign-in are required. A report in this week's issue of Science [Rubinfeld et al. (p. 1023)] places the tumor suppressor APC firmly in the signal transduction pathway triggered by WINGLESS (in the fruit fly Drosophila) and WNT (in the mouse). This pathway is a supremely important one for control of cell fate. A second report [Matsumine et al. (p. 1020)] identifies a new downstream target of APC, another tumor suppressor Drosophila discs large (dlg). In his Perspective, Peifer discusses what these findings may mean for how APC participates in cell fate control.

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      Keywords:

      NSDL,NSDL_SetSpec_BEN,colon cancer,tumor suppressor,regulation,signal transduction pathways,Life Science,oai:nsdl.org:2200/20110722025553584T,cell fate

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      English

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