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Other

Description:

The length of time that a voltage-dependent channel stays open can have a profound impact on the functional consequences of its opening. Together, Ca2+ and the Ca2+-binding protein calmodulin regulate the closing (Ca2+-dependent inactivation) and facilitate the opening (Ca2+-dependent facilitation) of voltage-gated Ca2+ channels. This review describes the features of calmodulin and its binding sites on voltage-gated Ca2+ channels that are likely to contribute to its ability to drive these opposing effects on channel activity.

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      Keywords:

      VGCC,Cav2.1,NSDL_SetSpec_BEN,Cav1.2,signal transduction,CaM,Life Science,oai:nsdl.org:2200/20080618224552053T,NSDL

      Language:

      English

      Access Privileges:

      Public - Available to anyone

      License Deed:

      Creative Commons Attribution Non-Commercial Share Alike

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