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Access to the article is free, however registration and sign-in are required. There are a huge number of membrane transporter proteins that transport molecules across the impermeable barrier presented by cellular membranes. In their Perspective, Locher et al. discuss a double tour de force (Abramson et al., Huang et al.), which provide structural determinations of two bacterial transporters, LacY and GlpT, and insights into how they work.
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