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Access to the article is free, however registration and sign-in are required. Certain membrane-spanning proteins expel hydrophobic molecules such as lipids and drugs from cells, but just how they accomplish this has been unclear. As Davidson and Chen describe in their Perspective, two new studies (Dong et al., and Reyes et al.) explain how a transporter protein called MsbA expends energy and changes its organization to flip a molecule from one side of the membrane to the other.
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