Type:

Other

Description:

Access to the article is free, however registration and sign-in are required. Structures of proteins for DNA replication in archaea suggest common mechanisms with sliding clamp loaders and DNA helicases. The initial step in duplicating a cellular genome is the unwinding of a limited region of double-stranded DNA to form a small single-stranded DNA bubble. In bacteria, archaea, and lower eukaryotes, the unwinding process begins at a sequence called the replication origin, which contains several conserved binding sites for a protein called the initiator. Reports by Gaudier et al. and by Dueber et al. solve high-resolution structures of archaean initiator protein-origin DNA complexes that reveal several unexpected and novel features of initiator protein function.

Subjects:

    Education Levels:

      Keywords:

      ORC (origin recognition complex),NSDL,NSDL_SetSpec_BEN,oai:nsdl.org:2200/20110722022843411T,Orc proteins,initiator proteins

      Language:

      English

      Access Privileges:

      Public - Available to anyone

      License Deed:

      Creative Commons Attribution Non-Commercial Share Alike

      Collections:

      None
      This resource has not yet been aligned.
      Curriki Rating
      'NR' - This resource has not been rated
      NR
      'NR' - This resource has not been rated

      This resource has not yet been reviewed.

      Not Rated Yet.

      Non-profit Tax ID # 203478467