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Access to the article is free, however registration and sign-in are required. Structural biologists have spent decades pondering the protein-folding problem, which seeks to explain how a simple string of amino acids self-assembles into a complex three-dimensional folded protein. In his Perspective, Jones explores progress in this arena, discussing the leap forward made by Kuhlman et al. These investigators have designed a protein from scratch on the computer and then synthesized and analyzed it in atomic detail using x-ray crystallography and NMR spectroscopy. The synthesized version of their new protein matches the computer prediction, representing a big step forward for the field of structural biology.

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      Keywords:

      protein structure,NSDL,NSDL_SetSpec_BEN,protein design,oai:nsdl.org:2200/20110722030819545T,protein folding,Life Science

      Language:

      English

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      Public - Available to anyone

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      Creative Commons Attribution Non-Commercial Share Alike

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