Type:

Other

Description:

This brief review serves as a refresher on smooth muscle physiology for those educators who teach in medical and graduate courses of physiology. Additionally, those professionals who are in need of an update on smooth muscle physiology may find this review to be useful. Smooth muscle lacks the striations characteristic of cardiac and skeletal muscle. Layers of smooth muscle cells line the walls of various organs and tubes in the body, and the contractile function of smooth muscle is not under voluntary control. Contractile activity in smooth muscle is initiated by a Ca2+-calmodulin interaction to stimulate phosphorylation of the light chain of myosin. Ca2+ sensitization of the contractile proteins is signaled by the RhoA/Rho kinase pathway to inhibit the dephosphorylation of the light chain by myosin phosphatase, thereby maintaining force generation. Removal of Ca2+ from the cytosol and stimulation of myosin phosphatase initiate the process of smooth muscle relaxation.

Subjects:

  • Education > General

Education Levels:

    Keywords:

    Content/background information,NSDL,NSDL_SetSpec_BEN,Instructional Material,Review,Activity,Large-group instruction,Cell signaling,oai:nsdl.org:2200/20080618222017755T,Life Science,Teacher-centered/traditional instruction,Education

    Language:

    English

    Access Privileges:

    Public - Available to anyone

    License Deed:

    Creative Commons Attribution Non-Commercial Share Alike

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