Type:

Other

Description:

Preconditioning by sublethal stress can protect a cell from subsequent injury and apoptosis through a mechanism that has been unclear. Many such stresses stimulate the formation of stress granules: transient cytoplasmic foci that contain heat shock protein as well as translationally stalled mRNA and various mRNA-binding proteins. Recent research suggests that sequestration in stress granules of TRAF2, an adaptor protein that is required for tumor necrosis factor receptor 1 signaling, may underlie preconditioning by sublethal stresses.

Subjects:

  • Mathematics > General

Education Levels:

    Keywords:

    oai:nsdl.org:2200/20080618215936655T,NSDL,NSDL_SetSpec_BEN,stress granule,apoptosis,signal transduction,TNF,Life Science,Mathematics,translation

    Language:

    English

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    Public - Available to anyone

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    Creative Commons Attribution Non-Commercial Share Alike

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