Type:

Other

Description:

Access to the article is free, however registration and sign-in are required. The enzyme PI 3-kinase seems to mediate extraordinarily diverse cellular responses to growth factors. In his Update Perspective, Hemmings offers an explanation by outlining the evidence for a common target of the phospholipid signaling molecules generated by PI 3-kinase--the pleckstrin homology (PH) domains located on at least 100 cellular proteins, which could mediate the diverse responses of cells. On p. 1927 of this issue, Klarlund et al. report the isolation of one of these PH domain-containing proteins, GRP1.

Subjects:

    Education Levels:

      Keywords:

      NSDL,pleckstrin homology (PH) domain,NSDL_SetSpec_BEN,adapter protein,Life Science,regulation,signaling,phosphoinositide 3-kinase (PI 3-kinase),oai:nsdl.org:2200/20110722030145548T

      Language:

      English

      Access Privileges:

      Public - Available to anyone

      License Deed:

      Creative Commons Attribution Non-Commercial Share Alike

      Collections:

      None
      This resource has not yet been aligned.
      Curriki Rating
      'NR' - This resource has not been rated
      NR
      'NR' - This resource has not been rated

      This resource has not yet been reviewed.

      Not Rated Yet.

      Non-profit Tax ID # 203478467