Type:

Other

Description:

Access to the article is free, however registration and sign-in are required. DNA viruses must first replicate their genome in the nucleus of the host cell before forming subviral particles that cross into the cytoplasm for the final stages of virion maturation. However, the nuclear envelope provides a physical barrier to the movement of subviral particles into the cytoplasm. In their Perspective, Sanchez and Spector discuss new work (Muranyi et al.) that reveals how cytomegalovirus recruits a host cell protein kinase C to modify the nuclear lamin meshwork of the nuclear envelope, thus enabling subviral particles to exit the nucleus.

Subjects:

    Education Levels:

      Keywords:

      herpesviruses,NSDL,NSDL_SetSpec_BEN,herpes simplex virus (HSV),protein kinase C (PKC),cytomagalovirus maturation,oai:nsdl.org:2200/20110722031003076T,virion,nuclear lamina,cytomegalovirus (CMV),b-herpesvirus,Viral envelope aquisition

      Language:

      English

      Access Privileges:

      Public - Available to anyone

      License Deed:

      Creative Commons Attribution Non-Commercial Share Alike

      Collections:

      None
      This resource has not yet been aligned.
      Curriki Rating
      'NR' - This resource has not been rated
      NR
      'NR' - This resource has not been rated

      This resource has not yet been reviewed.

      Not Rated Yet.

      Non-profit Tax ID # 203478467