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Access to the article is free, however registration and sign-in are required. How do retroviruses pass from an infected host cell to a new uninfected target cell? In a Perspective, Derse and Heidecker suggest an answer. According to new work, a virological synapse-analogous to the immunological synapse between immune cells-forms between T cells infected with HTLV-1 and uninfected T cells (Igakura et al.). Viral particles accumulate within the tight intercellular space of the virological synapse, which facilitates their passage into uninfected T cells.

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      Keywords:

      cell-to-cell transmission of retrovirus,NSDL,NSDL_SetSpec_BEN,human T cell lymphotropic virus-type 1 (HTLV-I,retroviruses,virological synapse,oai:nsdl.org:2200/20110722030952973T,microtubule organizing center (MTOC)

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      English

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