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Access to the article is free, however registration and sign-in are required. How do retroviruses pass from an infected host cell to a new uninfected target cell? In a Perspective, Derse and Heidecker suggest an answer. According to new work, a virological synapse-analogous to the immunological synapse between immune cells-forms between T cells infected with HTLV-1 and uninfected T cells (Igakura et al.). Viral particles accumulate within the tight intercellular space of the virological synapse, which facilitates their passage into uninfected T cells.
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